This section contains case studies, industry highlights, minireviews, and other articles for drug discovery professionals. Check out the resources page for posters, educational content, lists of drug approvals, and more.
What is it? Saridegib (IPI-926, patidegib) is a Smoothened receptor (SMO) antagonist and hedgehog pathway inhibitor currently in Ph. III…
molecule
4 weeks ago ●
4 mins read
In September 2022, deucravacitinib (Sotyktu), a first-in-class oral, allosteric tyrosine kinase 2 (TYK2) inhibitor for moderate-to-severe plaque psoriasis, was approved…
Article
5 months ago ●
7 mins read
What is it? Baxdrostat (RO6836191, CIN-107) is an oral aldosterone synthase (CYP11B2) inhibitor in several Ph. II trials (0.5-2 mg…
molecule
4 weeks ago ●
6 mins read
Abstract. Voxelotor, a gram-daily reversible covalent aldehyde drug, is an approved first-in-class oral drug that prevents the hemoglobin polymerization that…
Article
6 months ago ●
7 mins read
A metabolite and its parent: same target inhibition, different mechanisms. PF-6870961 is a growth hormone secretagogue receptor 1a (GHSR1a) inverse…
molecule
4 weeks ago ●
6 mins read
The real magic happens when chemists can integrate computational models into their assay cascades, thanks to trust in their predictions.…
Article
6 months ago ●
10 mins read
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