This section contains case studies, industry highlights, minireviews, and other articles for drug discovery professionals. Check out the resources page for posters, educational content, lists of drug approvals, and more.
DS34942424 is a potent oral analgesic discovered using the natural product conolidine as a starting point. While the authors were able…
molecule
2 years ago ●
1 min read
“compound 12” is a selective negative allosteric modulator of the GluN2B subunit of NDMA receptors intended for treatment of mood disorders.…
molecule
2 years ago ●
1 min read
“compound 37” is an inhibitor of the ATG7 E1 ligase through an interesting substrate-assisted covalent mechanism. Rather than covalently modify ATG7…
molecule
2 years ago ●
1 min read
“compound 20” is a gamma-secretase modulator (GSM) with an interesting, uncommon oxadiazine scaffold. Like many hot areas in drug discovery, the…
molecule
2 years ago ●
1 min read
A-1331852 is a highly potent, orally bioavailable inhibitor of BCL-XL, blocking a protein-protein interaction resulting in tumor cell apoptosis. The…
molecule
2 years ago ●
1 min read
dotinurad (FYU-981) potently inhibits uric acid uptake by renal proximal tubule epithelial cells, increasing uric acid urinary secretion which can help…
molecule
2 years ago ●
1 min read
Load More
