This section contains case studies, industry highlights, minireviews, and other articles for drug discovery professionals. Check out the resources page for posters, educational content, lists of drug approvals, and more.
PF-06826647 is a TYK2-selective kinase inhibitor which binds to the catalytically active JH1 kinase domain, in contrast to BMS-986165, a TYK2…
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2 years ago ●
1 min read
MSA-2 is an orally available agonist of the STING protein, which potently induces inflammation. Clinically evaluated cyclic dinucleotide-based STING agonists have…
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2 years ago ●
1 min read
SR-717 is STING agonist with a surprisingly similar mechanism to MSA-2, published contemporaneously with MSA-2. The identification of a second carboxylic…
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2 years ago ●
1 min read
Vixotrigine (BIIB074) is a voltage-gated sodium channel blocker that preferentially binds to the inactivated state of the sodium channels, conferring selectivity…
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2 years ago ●
1 min read
BI-3406 is a compound which binds to SOS1, preventing it from activating the oncoprotein KRAS. While inhibition of WT-KRAS and MEK…
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2 years ago ●
1 min read
“compound 3d” is a prodrug which is phosphorylated in vivo to form a potent sphingosine-1-phopshate receptor modulator. BMS took two…
molecule
2 years ago ●
1 min read
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