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A Billion-Dollar Aldosterone Synthase Inhibitor, an Oral KRASG12D Inhibitor Entering Development, and 14 More Molecules in the News

In this update of small molecules in the news we will cover recent:

  • (B)Million Dollar Molecules: recent mergers and acquisitions
  • Molecules in Motion: clinical trial updates and FDA filings
  • Molecules of the Month – Where Are They Now?: updates on past Drug Hunter MotM
  • Potential upcoming approvals: recent NDA filings and upcoming PDUFA dates

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Million-Dollar Molecules

baxdrostat 

This highly selective, oral aldosterone synthase (CYP11B2) inhibitor is being acquired by AstraZeneca via CinCor in a $1.8B transaction. The molecule is in several Ph. II trials (0.5-2 mg QD) for hypertension, CKD, and primary aldosteronism, appears to have demonstrated dose-dependent PK/PD and blood pressure response, and appears to be well-tolerated so far. CinCor licensed the molecule from Roche (RO6836191).

baxdrostat

oral aldosterone synthase (CYP11B2) inhibitor

acquired by AstraZeneca from CinCor for $1.8B

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